The linings of the nose, larynx, trachea and lungs are moistened by various glands, some of which may be absent, reduced in number or may not function normally in individuals affected by Ectodermal Dysplasia. The underproduction of mucus in the airways, together with constant nasal congestion, are a cause of frequent infections for which antibiotics are often necessary. Croup is a common problem in younger children and asthma is common to individuals of all ages. Individuals with either an infection or croup should be referred to a Doctor without delay.

Hoarseness of the voice is usually due to laryngeal (larynx = voice box) dryness and can be alleviated by using an air humidifier, especially in the bedroom throughout the night. In addition, nodules on the vocal cords have been reported. The effect of these on speech may improve with speech therapy, but in some individuals the nodules need to be removed.

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